2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-170635
    1-Palmitoyl-3-arachidoyl-rac-glycerol 90669-23-1 98%
    1-Palmitoyl-3-arachidoyl-rac-glycerol is a diacylglycerol that contains Palmitic acid (HY-N0830) at the sn-1 position and Arachidic acid (HY-W004260) at the sn-3 position
    1-Palmitoyl-3-arachidoyl-rac-glycerol
  • HY-170636
    1,2,3-Tri-10(Z)-undecenoyl glycerol 93824-29-4 98%
    1,2,3-Tri-10(Z)-undecenoyl glycerol is a triacylglycerol that contains 10-Undecenoic acid (HY-B0914) at the sn-1, sn-2, and sn-3 positions.
    1,2,3-Tri-10(Z)-undecenoyl glycerol
  • HY-170637
    1,3-Dinervonoyl glycerol 960594-30-3 98%
    1,3-Dinervonoyl glycerol is a diacylglycerol that contains Nervonic acid (HY-N2526) at the sn-1 and sn-3 positions.
    1,3-Dinervonoyl glycerol
  • HY-170638
    1,3-Dieicosatrienoin 960594-33-6 98%
    1,3-Dieicosatrienoin is a diacylglycerol that contains 11(Z),14(Z),17(Z)-Eicosatrienoic acid (HY-108398B) at the sn-1 and sn-3 positions.
    1,3-Dieicosatrienoin
  • HY-170639
    1,2-Diheptadecanoyl-rac-glycerol 98896-81-2 98%
    1,2-Diheptadecanoyl-rac-glycerol is a diacylglycerol that contains Heptadecanoic acid (HY-W004284) at the sn-1 and sn-2 positions.
    1,2-Diheptadecanoyl-rac-glycerol
  • HY-170641
    1-Palmitoyl-3-lauroyl-rac-glycerol 51604-53-6 98%
    1-Palmitoyl-3-lauroyl-rac-glycerol is a diacylglycerol that contains Palmitic acid (HY-N0830) and Lauric acid (HY-Y0366) at the sn-1 and sn-3 positions, respectively.
    1-Palmitoyl-3-lauroyl-rac-glycerol
  • HY-170676
    1,3-Dilinoleoyl-2-docosahexaenoyl glycerol 157363-75-2 98%
    1,3-Dilinoleoyl-2-docosahexaenoyl glycerol is a triacylglycerol that contains Linoleic acid (HY-N0729) at the sn-1 and sn-3 positions and Docosahexaenoic acid (HY-B2167) at the sn-2 position.
    1,3-Dilinoleoyl-2-docosahexaenoyl glycerol
  • HY-170677
    1,3-Ditridecanoyl glycerol 59891-27-9 98%
    1,3-Ditridecanoyl glycerol is a diacylglycerol that contains Tridecanoic acid (HY-Y1718) at the sn-1 and sn-3 positions.
    1,3-Ditridecanoyl glycerol
  • HY-170678
    1-Myristoyl-3-docosanoyl-rac-glycerol 115877-95-7 98%
    1-Myristoyl-3-docosanoyl-rac-glycerol is a diacylglycerol that contains Myristic acid (HY-N2041) at the sn-1 position and Docosanoic acid (HY-W013049) at the sn-3 position.
    1-Myristoyl-3-docosanoyl-rac-glycerol
  • HY-170679
    1,3-Dioctanoyl glycerol 1429-66-9 98.0%
    1,3-Dioctanoyl glycerol is a diacylglycerol that contains Octanoic acid (HY-41417) at the sn-1 and sn-3 positions.
    1,3-Dioctanoyl glycerol
  • HY-170680
    1,2-Dilinoleoyl-3-stearoyl-rac-glycerol 2190-17-2 98%
    1,2-Dilinoleoyl-3-stearoyl-rac-glycerol is a triacylglycerol that contains Linoleic acid (HY-N0729) at the sn-1 and sn-2 positions and Stearic acid (HY-B2219) at the sn-3 position.
    1,2-Dilinoleoyl-3-stearoyl-rac-glycerol
  • HY-170681
    1,3-Didocosanoyl-2-oleoyl glycerol 77145-68-7 98%
    1,3-Didocosanoyl-2-oleoyl glycerol is a triacylglycerol that contains Docosanoic acid (HY-W013049) at the sn-1 and sn-3 positions and Oleic acid (HY-N1446) at the sn-2 position.
    1,3-Didocosanoyl-2-oleoyl glycerol
  • HY-170796
    α-Amylase-IN-11 98%
    α-Amylase-IN-11 (compound C5f) is an α-Amylase inhibitor (IC50=0.56 μM) that can reduce the sugar level in vivo. α-Amylase-IN-11 has a moderate inhibitory effect on α-glucosidase (α-glucosidase), with IC50=11.03 μM. α-Amylase-IN-11 can significantly reduce the glucose concentration in a mouse model and has the potential for use in diabetes research.
    α-Amylase-IN-11
  • HY-170931
    AMPK activator 16 2252336-04-0 98%
    AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells.
    AMPK activator 16
  • HY-170943
    Antidiabetic agent 7 98%
    Antidiabetic agent 7 (Compound 5m) is hyperglycemic inhibitor. Antidiabetic agent 7 exhibits promising potency to stimulate GLUT4 translocation in skeletal muscle cells via activating AMPK-dependent pathway. Antidiabetic agent 7 reduces blood glucose levels. Antidiabetic agent 7 shows favorable pharmacokinetic properties. Antidiabetic agent 7 is potential to be used for anti-hyperglycemic research.
    Antidiabetic agent 7
  • HY-171000
    Propiverine N-oxide 111071-96-6 98%
    Propiverine N-oxide is the main metabolite of hydrochloride propiverine, and it can affect bladder contractions and saliva secretion in small pigs.
    Propiverine N-oxide
  • HY-171008
    Linoleoyl ethanolamide phosphate 419566-71-5 98%
    Linoleoyl ethanolamide phosphate is an intermediate in the biosynthesis of Linoleoyl ethanolamide (HY-113421). Linoleoyl ethanolamide phosphate combined with other endogenous N-acylethanolamines plays a role in the regulation of food intake by selective prolongation of feeding latency and post-meal interval.
    Linoleoyl ethanolamide phosphate
  • HY-171039
    Tribromobisphenol A 6386-73-8 98%
    Tribromobisphenol A (Tri-BBPA; 2,2',6-Tribromobisphenol A) is a phenolic compound isolated from human breast milk.
    Tribromobisphenol A
  • HY-171238
    Dihydroechinofuran 142130-52-7 98%
    Dihydroechinofuran is an abenzoquinone metabolite.
    Dihydroechinofuran
  • HY-171446
    TAK-075 667931-33-1 98%
    TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. TAK-075 can stimulate the transient secretion of parathyroid hormone (PTH) in rats and can effectively prevent a significant reduction in PTH secretion caused by the accumulation of active metabolites, maintaining the normal secretion pattern of PTH. TAK-075 can be used in the research of metabolic diseases and osteoporosis.
    TAK-075
Cat. No. Product Name / Synonyms Application Reactivity